What is clomidside effects, like other phenothiazines, dose dependent and usually caused pronounced pharmacological effects of the drug. In applying the drug in the recommended dosage range of adverse effects in the majority of cases are mild and transient in nature. Heavy phenomena observed at high.
CNS: sedation, drowsiness; dizziness; sometimes -Violation consciousness, agitation, hallucinations, irritability, headache; rarely – seizures, extrapyramidal symptoms (tremor, muscle rigidity, akathisia, dyskinesia, dystonia), tardive dyskinesia; very rarely – depression, insomnia, neuroleptic malignant syndrome. On the part of the autonomic nervous system / anticholinergic effects often -suhost mouth, blurred vision, paresis of accommodation, stuffy nose; -toshnota sometimes, vomiting, diarrhea, constipation, loss of appetite, delay or urinary incontinence; -blednost rarely, tremors; very rarely – paralytic ileus. On the part of the cardiovascular system: often – orthostatic hypotension;Sometimes, changes, tachycardia; rarely – arrhythmias; rarely -trepetanie, ventricular fibrillation, sudden death. On the part of the endocrine system: often, with a long reception – hyperprolactinemia, galactorrhea; sometimes – amenorrhea, menstrual irregularities, weight change, erectile dysfunction and ejaculation; rarely – priapism; very rarely – breast tenderness, gynecomastia, peripheral edema. On the part of the peripheral blood: rare – leukopenia, agranulocytosis, thrombocytopenia; very rarely – anemia, leukocytosis. Liver: sometimes – abnormal liver enzymes;rarely hepatitis.
For the skin: rarely – dermatitis, skin rashes (including allergic), urticaria, increased photosensitivity, angioedema. Other: rarely – in the area of the parotid gland swelling, hyperthermia, respiratory depression. When long-term therapy Tiodazinom there are reports of rare cases of pigment retinopathy developed in patients receiving the drug in doses exceeding the maximum recommended dose of 800 mg per day.
Drug Interactions: The metabolism mediated by cytochrome metabolized by the enzyme cytochrome what is clomid and, moreover, itself is an inhibitor of the pathway. Therefore drugs that inhibit this isoenzyme (eg, cimetidine, fluoxetine, paroxetine, moclobemide), may enhance the effects and prolong Tiodazina. Tritsklicheskie antidepressants . The simultaneous use of tricyclic antidepressants and phenothiazine derivatives may increase the plasma concentrations of drugs and / or phenothiazine derivative, which may cause cardiac arrhythmias. Anticonvulsants. As other phenothiazines, can reduce the seizure threshold. In an application what is clomid may increase or decrease serum concentrations of phenytoin, and therefore may need to dose adjustment. When used together Tiodazina and carbamazepine concentrations of these drugs in serum are not changed. Antihypertensives and beta-blockers.
Due to suppress metabolism combined use of these agents Tiodazinom can lead to increased plasma concentrations of each drug, which may possibly lead to hypotension, cardiac arrhythmias or side effects of the central nervous system. Indirect anticoagulants. The combined use of Tiodazinom may intensify gipoprotrombinemicheskogo action due primarily to the competitive interaction at the level of enzymes. In this case, careful monitoring of prothrombin concentration in the plasma. The funds from the depressing effect on the central nervous system. May enhance the effects of alcohol and other means, have a depressing effect on the central nervous system, benzodiazepines, opioids, barbiturates, antidepressants, and for anesthesia. Concomitant use inhibitors can lengthen and intensify the sedative and antimuscarinic action of each of the drugs. Lithium preparations . You may experience severe neurotoxic complications, extrapyramidal disorders and somnambulism in patients receiving both drugs lithium and phenothiazine, including what is clomid. Means with anticholinergic action . In an application with Tiodazinom may increase anticholinergic effects of M-anticholinergics (atropine funds), antihistamines and tricyclic antidepressants, until such manifestations as “atropinovy psychosis”, pronounced constipation, paralytic ileus, hyperpyrexia with possible heat stroke. In these cases, it shows a thorough observation of the patient and correction of doses of drugs.
Antiparkinsonian agents. In an application Tiodazina and levodopa may weaken the effects of each of the drugs. Vasoconstrictor. With its ɑ-adrenoceptor blocking properties Tiodazin may weaken the pressor effect vasoconstrictor (epinephrine, dopamine , ephedrine, phenylephrine). quinidine . With simultaneous use of quinidine and Tiodazina may increase depressant effects of quinidine on the myocardium. Antiarrhythmic agents / elongation interval . Given that phenothiazines, including can cause such changes as a lengthening of the interval , caution should be exercised in their simultaneous application with the drugs having a similar property. Thiazide diuretics. . The simultaneous use of and thiazide diuretics can lead to severe hypotension . In addition, due diuretic hypokalemia may enhance the cardiotoxic effects Tiodazina. Antidiabetics. Effect on carbohydrate metabolism, and therefore in its application could disrupt the stability of the patient achieved during treatment antidiabetic agents. Antacids and antidiarrheal agents may reduce the absorption from the gastrointestinal -kishechnogo tract.
with special caution in patients with glaucoma (especially the closure form), cardiovascular diseases, severe respiratory diseases, renal failure, Parkinson’s disease, epilepsy, prostatic hypertrophy, myasthenia gravis, pheochromocytoma. During treatment Tiodazinom prohibited alcohol intake, as well as driving vehicles, using machinery, and other activities that require quick response.
Increased side effects, the appearance of acute neuroleptic reactions. Especially should guard increase in body temperature, which can be one of the symptoms of neuroleptic malignant syndrome. In severe cases an overdose may experience different forms of impairment of consciousness up to coma.
Aid Measures: cessation of therapy Tiodazinom and any other antipsychotic drugs (neuroleptics), the appointment of correctors (central anticholinergics), administration of high doses of activated charcoal, gastric lavage, in convulsions intravenous diazepam, glucose solution, nootropics, vitamins , close monitoring of the cardiovascular, respiratory and central nervous system, symptomatic therapy.
In convulsions barbiturates should be avoided because they may increase the respiratory depression caused by phenothiazine derivatives.