clomiphene for men

The maximum clomiphene for men concentration in the blood plasma of 109 ug / ml, time to maximum plasma concentration – 1.18 h, binding to blood proteins do not exceed 10%.

Injection: Maximum concentration  .. In plasma after intramuscular administration – 399 ug / ml, time to maximum concentration – 0, 84 hours after intramuscular and 0.1 h after intravenous injection, the volume of 318.0 ml, the absolute degree of biological 34.6% availability. At high concentrations steroids for sale uk
the drug accumulates in the tissues of the heart, liver, spleen, kidney and colon, in small amounts – in the small intestine and lung.

Indications
of liver toxicity, including alcoholic or viral origin and the drug (antibiotics, antineoplastic, antitubercular, antiviral drugs, tricyclic antidepressants, oral contraceptives, etc.). Chronic alcoholic hepatitis moderate minimal activity. Chronic viral hepatitis, fatty liver, cirrhosis of the liver.

Contraindications
: Hypersensitivity to the drug; renal failure; childhood; during pregnancy and lactation.

. Dosage and administration . Inside  appoint 1 – 2 tablets 3-4 times a day for 20 – 30 days. Duration of treatment is determined by the physician individually depending on the severity and characteristics of the disease.

Parenterally. In chronic hepatitis clomiphene for men in the first five days of illness injected intramuscularly with 2 ml of 2.5% solution 2-3 times a day (2-3 x 50 mg), or by slow intravenous injection at a rate of 2 ml / min 4 ml of a 2.5% solution (100 mg) or a drip at a rate of 20-30 drops per minute (2 ampoules of 2.5% solution dissolved in 150-250 ml of saline). From the fifth day to the twentieth  treatment prescribed tablets (100 mg three times a day). The course of treatment – 20-30 days.

. Side effects
Rarely:

  • from the gastrointestinal tract: nausea, dry mouth, flatulence;
  • from the central and peripheral nervous system: general weakness, dizziness, tinnitus;
  • on the part of the cardiovascular system: tachycardia, increased blood pressure, chest pain, arrhythmia;
  • on the part of the respiratory system: very rarely – shortness of breath, attacks of breathlessness.
  • allergic reactions: hypersensitivity reactions, fever, rarely – angioedema.
  • with the skin: itching, flushing of the skin, urticaria.

 

Overdose.
Cases of overdose are unknown clomiphene for men. If ingestion of a large amount of the drug – it is necessary to do a gastric lavage. Treatment is symptomatic.

. Cautions
The composition includes sucrose tablet – 2.8 mg per one tablet i.e. maximum daily dosage (8 tablets) contains 22.4 mg of sucrose, which should be considered in patients with diabetes mellitus.

clomid success rate

Clomid success rate, psychotic disorders, accompanied by hyperactivity and psychomotor agitation; behavioral disorders associated with psychotic disorders and / or neurological diseases; moderate depressive disorders; neuroses, accompanied by anxiety, agitation, tension, fear.

Contraindications

Severe depression, coma, marked depression, blood diseases in history, children under 2 years of age, severe diseases of the cardiovascular system, liver failure, increased sensitivity to thioridazine and other derivatives of phenothiazine.

Pregnancy and lactation

In pregnancy, the use of Tiorila possible only if the expected benefit to the mother outweighs the potential risk to the fetus. Adequate and well-controlled studies of drug safety in pregnancy has not been. The appointment Tiorila during lactation should stop breastfeeding.

dosage

Selected individually taking into account clomid success rate the genesis of symptoms and degrees of severity. The daily dose for adults and children over 12 years is 20 – 600 mg / day, the multiplicity of applications – 2-4 times a day. The maximum dose – 800 mg per day. The course of treatment with high doses does not continue for more than 4 weeks.
Children aged 2 to 5 years – 1 mg / kg / day. Children over 5 years old usually prescribed 75 mg / day, the multiplicity of reception – 2-4 times a day.

Side effect

CNS: possible drowsiness, confusion, anxiety, akathisia, headache, blurred vision; in rare cases – neuroleptic malignant syndrome; convulsions because Tioril may lower the seizure threshold. Prolonged use may extrapyramidal disorders. In high doses, are more likely than other phenothiazines, causes pigment retinopathy. In very rare cases, long-term use can tardive dyskinesias.

From the digestive system:possible dry mouth, constipation, nausea, vomiting, hypertrophy of papillae language, rarely – paralytic ileus, cholestatic hepatitis. Since the cardiovascular system: possible postural hypotension ( especially in elderly patients), cardiac arrhythmia, tachycardia. In high doses, as well as other phenothiazines, particularly with concomitant hypokalemia, can cause changes in the clomid success rate the interval , smoothing of  wave, the appearance of the tooth U. From the hematopoietic system: in rare cases – leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, granulocytopenia , eosinophilia, pancytopenia. From endocrine system: possible hyperprolactinemia, menstrual disorders, abnormal ejaculation, decreased libido. On the part of metabolism: long-term use at high doses may develop melanosis. The respiratory system: nasal congestion. Allergic reactions: possible skin rash, itching, angioedema, exfoliative dermatitis. Other: possible incontinence or urinary retention; rarely – increased body mass index, photophobia, blurred vision.

Overdose

Symptoms: increased drowsiness, confusion, urinary retention, depression of the respiratory center, hypotension, disorientation, areflexia, hyperreflexia, convulsions, arrhythmia. In severe cases, coma, collapse. Treatment: gastric lavage, followed by the appointment of activated carbon. Treatment is symptomatic, with hypotension shows the introduction of plasma substitutes.

Interaction with other drugs

In an application Tiorila with other drugs, have a depressing effect on the central nervous system, as well as ethanol and etanolosoderzhaschimi drugs may increase depression; with levodopa – protivoparkinsonicheskogo reduction actions; with lithium preparations – possible neurotoxic effects. Tioril may reduce the plasma concentration of phenobarbital, reduce the effect of anticoagulants and oral antidiabetics. Undesirable anticholinergic effects Tiorila may be increased by concomitant use of anticholinergic drugs.

special instructions

To use caution in patients with cardiac arrhythmias, heart disease, severe respiratory diseases, renal failure, clomid success rate disease, narrow-angle glaucoma, prostatic hypertrophy, myasthenia gravis, epilepsy, phaeochromocytoma. During treatment, avoid alcohol.
Patients with liver disease require regular monitoring of liver function. Elderly patients, debilitated or suffering from kidney disease or liver recommended to prescribe lower starting dose with gradual increase it.

Effects on ability to drive vehicles and management mechanisms :

During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

release Form

10 tablets in a blister made film and aluminum foil. 3 blisters or 10 blisters of 10 tablets with instructions for use in a cardboard box.
The sample is not for sale: 4 or 10 tablets in a blister made film and aluminum foil. 1 blister with instructions for use in a cardboard box.

side effects of clomid

When ingestion rapidly and completely absorbed from the gastrointestinal tract. Taking the drug together with a meal can reduce the absorption of the drug. The maximum plasma concentration is reached within 30 minutes after administration of side effects of clomid and 4 ug / ml. The drug has the effect of “first pass” through the liver, the absolute bioavailability of thioctic acid is 20%. The half-life – 25 minutes. The main pathway – oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%).

 

Indications

Diabetic and alcoholic polyneuropathy.

 

Contraindications

Hypersensitivity to thioctic acid or other ingredients.

Pregnancy, lactation (not enough experience with the drug).

Clinical data on the use side effects of clomid in children and adolescents lacking in this regard to children and adolescents should not be prescribed the drug.

 

Dosing and Administration

The drug is administered orally. The recommended dose – 1 tablet (600 mg), 1 time per day. The drug is taken on an empty stomach, 30 minutes before breakfast without chewing, washing down with water.

In severe cases, treatment is initiated with the appointment  solution for intravenous administration for 2 – 4 weeks, then transferred to the patient’s treatment .

 

 

From the gastrointestinal tract :

Often – a nausea; very rarely – vomiting, pain in the stomach and intestines, diarrhea, change in taste.

Allergic reactions: very rare – skin rash, urticaria, pruritus, anaphylactic shock.

From the nervous system and sensory organs: often – dizziness.

General nature:

Very rare – due to improved glucose utilization may decrease the level of glucose in the blood and may appear symptoms of hypoglycemia (confusion, sweating, headache, visual disturbances).

 

Overdose

Symptoms:

In the case of receiving thioctic (a-lipoic acid) in doses of 10-40 g can be observed signs of severe intoxication (generalized seizures, expressed disturbances of acid-base balance, leading to lactic acidosis, hypoglycemic coma, severe bleeding disorders, sometimes resulting in fatal ).

If you suspect that a significant overdose of the drug (dose equivalent of more than 10 tablets for adults or more than 50 mg / kg of body weight for a child) needed immediate hospitalization.

Treatment: symptomatic, if necessary – anticonvulsant therapy, measures to support the functions of vital organs.

 

Interaction with other drugs

When concomitant administration of thioctic acid and cisplatin marked decrease in the efficiency of cisplatin. Thioctic acid binds the metals, so it should not be administered concurrently with drugs containing metals (eg, iron supplements, magnesium, calcium). According to a preferred method of administration, tablets side effects of clomid take 30 minutes before breakfast, while preparations containing metals should be taken in the afternoon or evening. For the same reason, the period of treatment  is recommended consumption of dairy products in the second half of the day.

With simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs their action can be amplified, so we recommend regular monitoring of blood glucose levels, especially at the beginning of therapy thioctic acid. In some cases the permissible reduction in the dose of hypoglycemic drugs to prevent the development of symptoms of hypoglycemia.

 

Ethanol and its metabolites weaken the effect of thioctic acid.

 

special instructions

Alcohol consumption is a risk factor for the development of polyneuropathy and may decrease the effectiveness side effects of clomid, therefore patients should abstain from alcohol during treatment as a drug, and in the periods outside of treatment.

diabetic polyneuropathy Treatment should be carried out against the background of maintaining optimal blood glucose levels.

chlomid

The main pathway – oxidation and chlomid conjugation. The volume of distribution – about 450 ml / kg. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half-life – 20 -50 minutes. The total plasma clearance – 10-15 ml / min.

Indications

Diabetic and alcoholic polyneuropathy.

Contraindications

Hypersensitivity to thioctic acid or other ingredients.

Pregnancy, lactation (not enough experience with the drug).

Clinical data on the use of the drug chlomid  in children and adolescents lacking in this regard to children and adolescents should not be prescribed the drug.

 

Dosing and Administration

The drug is used intravenously. The recommended dose for severe polyneuropathy is 1 vial (600 mg) 1 times a day for 2-4 weeks.

Subsequently, the patient is transferred to the treatment with Thioctacid ® BV is 600 mg (1 tablet) per day.

Intravenous administration of the drug should be carried out slowly (not faster than 2 ml / min).

Intravenous administration is also possible by using undiluted solution injection syringe and pump reliability. In this case, the time of administration should be not less than 12 minutes.

Because of the sensitivity to the light chlomid of the active substance, ampoules must be removed from the carton immediately prior to use.

Recommendations for infusion

The infusion solution should be protected from light (eg by wrapping the container with aluminum foil).

Solution for intravenous administration, protected from light, fit for 6 hours.

Allergic reactions:

Rarely – skin rash, hives, itching, eczema, redness of the skin, systemic allergic reactions up to anaphylactic shock.

From the nervous system and sensory organs: very rare – convulsions, diplopia.

From the blood and circulatory system:

Very rarely – purpura, petechiae and bleeding tendency (due to platelet function disorders), thrombocytopathy, thrombophlebitis.

General nature:

Often – by rapid intravenous injection can be observed an increase in intracranial pressure and difficulty breathing, which chlomid independently tested.

Nechasto- impaired sense of taste (metallic taste).

Rarely allergic reactions may occur at the site of infusion.

Rarely – nausea and vomiting.

Very rare – due to improved glucose utilization may decrease the level of glucose in the blood and appear symptoms of hypoglycemia (confusion, sweating, headache, visual disturbances).

 

 

Overdose

Cases of drug overdose thioctic acid in the form of a solution is not observed for intravenous administration.

If peredozirovki- symptomatic treatment, if necessary – anticonvulsant therapy, measures to support the functions of vital organs.

 

Interaction with other drugs

When concomitant administration of thioctic acid and cisplatin marked decrease in the efficiency of cisplatin. With simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs their action can be amplified, so we recommend regular monitoring of blood glucose levels, especially at the beginning of therapy thioctic acid. In some cases the permissible reduction in the dose of hypoglycemic drugs to prevent the development of symptoms of hypoglycemia.

Ethanol and its metabolites weaken the effect of thioctic acid.

 

special instructions

Thioctic acid infusion solution is incompatible with dextrose, Ringer’s solution, and solutions of reacting with disulfide  with ethanol. Alcohol consumption is a risk factor for the development of polyneuropathy and may decrease the effectiveness of the drug , so patients should abstain from alcohol during treatment as a drug, and in the periods outside of treatment.

diabetic polyneuropathy Treatment should be carried out against the background of maintaining optimal blood glucose levels.

 

release Form

A solution for intravenous administration of 25 mg / ml.

In 24 ml of solution in a dark glass vial, hydrolytic type 1 Directly on the vial marked to show the place chlomid of application of force for opening the ampoule: two rings of red and white point.

5 vials in a plastic tray white, 1 pallet together with instructions for use in a cardboard box.

what is clomid

What is clomidside effects, like other phenothiazines, dose dependent and usually caused pronounced pharmacological effects of the drug. In applying the drug in the recommended dosage range of adverse effects in the majority of cases are mild and transient in nature. Heavy phenomena observed at high.

CNS: sedation, drowsiness; dizziness; sometimes -Violation consciousness, agitation, hallucinations, irritability, headache; rarely – seizures, extrapyramidal symptoms (tremor, muscle rigidity, akathisia, dyskinesia, dystonia), tardive dyskinesia; very rarely – depression, insomnia, neuroleptic malignant syndrome. On the part of the autonomic nervous system / anticholinergic effects often -suhost mouth, blurred vision, paresis of accommodation, stuffy nose; -toshnota sometimes, vomiting, diarrhea, constipation, loss of appetite, delay or urinary incontinence; -blednost rarely, tremors; very rarely – paralytic ileus. On the part of the cardiovascular system: often – orthostatic hypotension;Sometimes, changes, tachycardia; rarely – arrhythmias; rarely -trepetanie, ventricular fibrillation, sudden death. On the part of the endocrine system: often, with a long reception – hyperprolactinemia, galactorrhea; sometimes – amenorrhea, menstrual irregularities, weight change, erectile dysfunction and ejaculation; rarely – priapism; very rarely – breast tenderness, gynecomastia, peripheral edema. On the part of the peripheral blood: rare – leukopenia, agranulocytosis, thrombocytopenia; very rarely – anemia, leukocytosis. Liver: sometimes – abnormal liver enzymes;rarely hepatitis.

For the skin: rarely – dermatitis, skin rashes (including allergic), urticaria, increased photosensitivity, angioedema. Other: rarely – in the area of the parotid gland swelling, hyperthermia, respiratory depression. When long-term therapy Tiodazinom there are reports of rare cases of pigment retinopathy developed in patients receiving the drug in doses exceeding the maximum recommended dose of 800 mg per day.

Drug Interactions: The metabolism mediated by cytochrome  metabolized by the enzyme cytochrome what is clomid and, moreover, itself is an inhibitor of the pathway. Therefore drugs that inhibit this isoenzyme (eg, cimetidine, fluoxetine, paroxetine, moclobemide), may enhance the effects and prolong Tiodazina. Tritsklicheskie antidepressants . The simultaneous use of tricyclic antidepressants and phenothiazine derivatives may increase the plasma concentrations of drugs and / or phenothiazine derivative, which may cause cardiac arrhythmias. Anticonvulsants.  As other phenothiazines, can reduce the seizure threshold. In an application what is clomid may increase or decrease serum concentrations of phenytoin, and therefore may need to dose adjustment. When used together Tiodazina and carbamazepine concentrations of these drugs in serum are not changed. Antihypertensives and beta-blockers.

Due to suppress metabolism combined use of these agents Tiodazinom can lead to increased plasma concentrations of each drug, which may possibly lead to hypotension, cardiac arrhythmias or side effects of the central nervous system. Indirect anticoagulants. The combined use of Tiodazinom may intensify gipoprotrombinemicheskogo action due primarily to the competitive interaction at the level of enzymes. In this case, careful monitoring of prothrombin concentration in the plasma. The funds from the depressing effect on the central nervous system.  May enhance the effects of alcohol and other means, have a depressing effect on the central nervous system, benzodiazepines, opioids, barbiturates, antidepressants, and for anesthesia.  Concomitant use inhibitors can lengthen and intensify the sedative and antimuscarinic action of each of the drugs. Lithium preparations . You may experience severe neurotoxic complications, extrapyramidal disorders and somnambulism in patients receiving both drugs lithium and phenothiazine, including what is clomid. Means with anticholinergic action . In an application with Tiodazinom may increase anticholinergic effects of M-anticholinergics (atropine funds), antihistamines and tricyclic antidepressants, until such manifestations as “atropinovy psychosis”, pronounced constipation, paralytic ileus, hyperpyrexia with possible heat stroke. In these cases, it shows a thorough observation of the patient and correction of doses of drugs.

Antiparkinsonian agents. In an application Tiodazina and levodopa may weaken the effects of each of the drugs. Vasoconstrictor. With its ɑ-adrenoceptor blocking properties Tiodazin may weaken the pressor effect vasoconstrictor (epinephrine, dopamine , ephedrine, phenylephrine). quinidine . With simultaneous use of quinidine and Tiodazina may increase depressant effects of quinidine on the myocardium. Antiarrhythmic agents / elongation  interval . Given that phenothiazines, including can cause such changes  as a lengthening of the interval , caution should be exercised in their simultaneous application with the drugs having a similar property. Thiazide diuretics. . The simultaneous use of  and thiazide diuretics can lead to severe hypotension . In addition, due diuretic hypokalemia may enhance the cardiotoxic effects Tiodazina. Antidiabetics.  Effect on carbohydrate metabolism, and therefore in its application could disrupt the stability of the patient achieved during treatment antidiabetic agents. Antacids and antidiarrheal agents may reduce the absorption from the gastrointestinal -kishechnogo  tract.

Cards
with special caution in patients with glaucoma (especially the closure form), cardiovascular diseases, severe respiratory diseases, renal failure, Parkinson’s disease, epilepsy, prostatic hypertrophy, myasthenia gravis, pheochromocytoma. During treatment Tiodazinom prohibited alcohol intake, as well as driving vehicles, using machinery, and other activities that require quick response.

Overdose.
Increased side effects, the appearance of acute neuroleptic reactions. Especially should guard increase in body temperature, which can be one of the symptoms of neuroleptic malignant syndrome. In severe cases an overdose may experience different forms of impairment of consciousness up to coma.
Aid Measures: cessation of therapy Tiodazinom and any other antipsychotic drugs (neuroleptics), the appointment of correctors (central anticholinergics), administration of high doses of activated charcoal, gastric lavage, in convulsions intravenous diazepam, glucose solution, nootropics, vitamins , close monitoring of the cardiovascular, respiratory and central nervous system, symptomatic therapy.
In convulsions barbiturates should be avoided because they may increase the respiratory depression caused by phenothiazine derivatives.