clomiphene

Timolol maleate is rapidly penetrates the cornea of the eye tissue. The small amount reaches the systemic circulation by absorption through the conjunctiva, the mucous membranes of the nose and the lachrymal tract. Excretion clomiphene of metabolites – the kidneys. In infants and young children the concentration of the active substance greatly exceeds its maximum plasma concentration in adults.

Indications for use:

  • Primary open-angle glaucoma;
  • secondary glaucoma (uveal, afakicheskaya, posttraumatic)
  • congenital glaucoma (with the ineffectiveness of other therapeutic measures);
  • a sharp rise in intraocular pressure;
  • primary angle-closure glaucoma (in combination with miotikami).

Application with caution: sinoatrial block, hypotension, children, especially during the clomiphene, cerebrovascular insufficiency, diabetes, hypoglycemia, hyperthyroidism, myasthenia gravis, concurrent administration of other beta-blockers.

Pregnancy and lactation:

In pregnancy, the drug is used, if the expected benefit to the mother outweighs the potential risk to the fetus. During the use of the drug should stop breastfeeding.

Dosage and administration:

Infants and children up to 10 years, 1 drop was instilled 0.25% solution, 2 times a day. Adults and children over 10 years instilled in the conjunctival sac of one drop of 0.25% solution of 2 times a day, the lack of effectiveness – 1 drop of 0.5% solution of 2 times a day, if necessary dose can be reduced to 1-2 drops of 1 per day .

Before each instillation necessary to remove the protective .
Prior to the first use of the drug vial flip the dropper vertically downwards and push its base (bottom) several times, until the tip of the dropper appears in the first drop. Thereafter the vial is ready for use.
When the drug instillation hold the dropper bottle down quickly and forcefully pressing on his base (bottom). Thus, a mechanism is actuated only extracted a dropper and one drop of formulation. A special valve system design dropper provides always the same size extracted drops and the same rate of its extraction even with a very strong pressure on the vial bottom.

Side effect

Local reactions:
irritation of the eyes, which manifests itself in the form of conjunctivitis, blepharitis, keratitis (hyperemia of the eyelid skin, burning and itching in the eyes, conjunctival hyperemia, tearing or decrease lacrimation, photophobia, edema of the corneal epithelium, a short break in visual acuity, prolonged use may develop superficial keratopathy point (decrease the transparency clomiphene of the cornea) and reduction in the sensitivity of the cornea), ptosis, diplopia;

Systemic reactions:
Cardio-vascular system: decrease in blood pressure, bradycardia, bradyarrhythmia, atrioventricular block, heart failure, heart failure, decreased myocardial contractility, chest pain, transient ischemic attack, collapse,
part of the respiratory system: dyspnea, bronchospasm , pulmonary insufficiency,
the part of the central nervous system: dizziness, headache, drowsiness, hallucinations, slow the speed of psychomotor reactions;
Other side effects: allergic reactions (including hives), rhinitis, nasal congestion, nosebleeds, nausea, vomiting , diarrhea, paresthesia, muscle weakness, sexual dysfunction, depression.

Overdose

When applied topically in the recommended dose overdose symptoms are not observed. In case of accidental ingestion may develop the following symptoms: nausea, vomiting, dizziness, headache, decreased blood pressure, bronchospasm, bradycardia. In the case of symptoms of symptomatic treatment Isoprenaline overdose can be administered intravenously to correct bradycardia or bronchospasm, dobutamine to treat hypotension.

Interaction with other drugs

Epinephrine, pilocarpine, systemic beta-blockers increase the effect. When applied with reserpine – may develop bradycardia or hypotension (this combination requires careful medical supervision); with calcium channel blockers or cardiac glycosides – may impair atrioventricular conduction, acute left ventricular failure or hypotension. It enhances the action of muscle relaxants (timolol should be canceled 48 hours before the expected general anesthesia with the use of peripheral muscle relaxants). You can not simultaneously be used clomiphene with antipsychotic drugs (neuroleptics) and anxiolytic drugs (tranquilizers) During treatment it is not recommended to take ethanol (perhaps a sharp decrease in blood pressure). With caution in conjunction with antihypertensive drugs, other beta-blockers, insulin or oral hypoglycemic drugs, corticosteroids, psychoactive drugs.

special instructions

Efficiency control should be about 3-4 weeks after initiation of therapy. During treatment at least 1 time in 6 months should be controlled tearing function, the integrity of the field of view of the cornea. During the period of treatment must be careful when driving and other activities potentially hazardous activities that require high concentration and psychomotor speed reactions and good vision (for 0.5 hours after instillation of the eye).

Contact lenses should be removed prior to instillation and put on no earlier than 15 minutes after it.

Prolonged use may weaken the effect of timolol. Before the upcoming surgery with general anesthesia – 48 hours to cancel the drug.

The original design of bottle-dropper, which operates on the principle of airless pump does not allow outside air to penetrate into the bottle and thus provides sterile eye drops without preservatives in their structure.

The use of timolol eye drops, PIC [without preservative] avoids the undesirable effects of preservative to the external eye tissue, conjunctiva and cornea, and – eliminates the risk of allergic reactions to the preservative.

After opening the bottle, and the first instillation of timolol eye drops, PIC [without preservative] the drug can be used for 12 weeks. To do this, mark on the vial and / or a cardboard bundle the date when you first dripped drug. On the bottle label and the carton pack, a special graph to fill the patient:. “The first application date”

 

After use, the contents of the vial should buy a new vial; used bottle is not suitable for re-use and must be disposed of clomiphene (discard the used bottle in the trash).

clomid

Timolol maleate is rapidly clomid penetrates the cornea of the eye tissue. The small amount reaches the systemic circulation by absorption through the conjunctiva, the mucous membranes of the nose and the lachrymal tract. Excretion of metabolites – the kidneys. In infants and young children the concentration of the active substance greatly exceeds its maximum plasma concentration in adults.

Indications

– Primary open-angle glaucoma;
– secondary glaucoma (uveal, afakicheskaya, posttraumatic)
– congenital glaucoma (with the ineffectiveness of other therapeutic measures);
– a sharp rise in intraocular pressure;
– primary angle-closure glaucoma (in combination with miotikami).

Contraindications

– Chronic obstructive pulmonary disease, severe course including – asthma,
– sinus bradycardia (slow heartbeat)
– atrioventricular block II and III level;
– acute and chronic heart failure II and III level;
– cardiogenic shock;
– degenerative corneal disease;
– severe vasomotor rhinitis;
– hypersensitivity to the drug.

Application with caution : sinoatrial block, hypotension, children, especially the newborn period, cerebrovascular insufficiency, diabetes, hypoglycemia, hyperthyroidism, myasthenia gravis, concurrent administration of other beta-blockers.

Pregnancy and lactation:

In pregnancy, the drug is used, if the expected benefit to the mother outweighs the potential risk to the fetus. During the use of the drug should stop breastfeeding.

Dosing and Administration

Before each instillation necessary to remove the protective cap clomid.
Prior to the first use of the drug vial flip the dropper vertically downwards and push its base (bottom) several times, until the tip of the dropper is not the first drop appears (see. Fig. 2) . Thereafter the vial is ready for use.
When the drug instillation hold the dropper bottle down quickly and forcefully pressing on his base (bottom). Thus, a mechanism is actuated only extracted a dropper and one drop of formulation. A special valve design of the system provides a dropper always the same size drops and extracted the same rate of its extraction even with a very strong pressure on the vial bottom. Tilt the head back slightly, slightly pull the lower eyelid with your finger and drip one drop into the conjunctival sac, as described above. Slowly close your eyes.
After the procedure immediately tightly put on a drip .
When backfilling should avoid contact with the surface of the dropper tip eyes and skin.

Side effect

Local reactions:
irritation of the eyes, which manifests itself in the form of conjunctivitis, blepharitis, keratitis (hyperemia of the eyelid skin, burning and itching in the eyes, conjunctival hyperemia, tearing or decrease lacrimation, photophobia, edema of the corneal epithelium, a short break in visual acuity, prolonged use may develop superficial keratopathy point (decrease the transparency of the cornea) and reduction in the sensitivity of the cornea), ptosis, diplopia;

Systemic reactions:
Cardio-vascular system: decrease in blood pressure, bradycardia, bradyarrhythmia, atrioventricular block, heart failure, heart failure, decreased myocardial contractility, chest pain, transient ischemic attack, collapse,
part of the respiratory system: dyspnea, bronchospasm , pulmonary insufficiency,
the part of the central nervous system: dizziness, headache, drowsiness, hallucinations, slow the speed of psychomotor reactions;
Other side effects: allergic reactions (including hives), rhinitis, nasal congestion, nosebleeds, nausea, vomiting , diarrhea, paresthesia, muscle weakness, sexual dysfunction, depression.

Overdose

When applied topically in the recommended dose overdose symptoms are not observed. In case of accidental ingestion may develop the following symptoms: nausea, vomiting, dizziness, headache, decreased blood pressure, bronchospasm, bradycardia. In case of overdose symptomatic treatment clomid of symptoms. Isoprenaline can be administered intravenously to correct bradycardia or bronchospasm, dobutamine to treat hypotension.

Interaction with other drugs

Epinephrine, pilocarpine, systemic beta-blockers increase the effect. When applied with reserpine – may develop bradycardia or hypotension (this combination requires careful medical supervision); with calcium channel blockers or cardiac glycosides – may impair atrioventricular conduction, acute left ventricular failure or hypotension. It enhances the action of muscle relaxants (timolol should be canceled 48 hours before the expected general anesthesia with the use of peripheral muscle relaxants). You can not simultaneously be used with antipsychotic drugs (neuroleptics) and anxiolytic drugs (tranquilizers).During treatment is not recommended to take ethanol (perhaps a sharp decrease in blood pressure). With caution in conjunction with antihypertensive drugs, other beta-blockers, insulin or oral hypoglycemic drugs, corticosteroids, psychoactive drugs.

Special instructions:

Efficiency control should be about 3-4 weeks after initiation of therapy. During treatment at least 1 time in 6 months should monitor the function of tearing, the integrity of the cornea, the field of view. During the period of treatment must be careful when driving and other activities potentially hazardous activities that require high concentration and psychomotor speed reactions and good vision (for 0.5 hours after instillation of the eye).
Contact lenses should be removed prior to instillation and put no earlier than 15 minutes after it.
with prolonged use of timolol may weaken the effect.
Before the upcoming surgery with general anesthesia -. 48 hours preparation cancel
original design of bottle-dropper, which operates on the principle of airless pump does not allow outside air to penetrate into bottle and thus provides sterile eye drops in the absence of their composition a preservative.
the use of “timolol-PIC eye drops [without preservative] avoids the undesirable effects of preservative to external ocular tissue, conjunctiva and cornea, and – eliminates the risk of allergic reactions to the preservative .
After opening the bottle, and the first instillation of timolol eye drops, PIC [without preservative] the drug can be used for 12 weeks. To do this, mark on the vial and / or a cardboard bundle the date when
you first dripped drug. On the bottle label and the carton pack, a special graph to fill the patient: “The date of the first application.”

After using the vial contents clomid should buy a new vial; used bottle is not suitable for re-use and must be disposed of (discard the used bottle in the trash)

clomid for men

Clomid for men administered intramuscularly 1 ml daily for 2 weeks in the treatment with prednisolone . After 7-10 days of treatment the daily dose of prednisone is reduced , followed by gradual reduction of the dose of prednisolone (5 mg every 4-5 days). If necessary, keep a maintenance dose of prednisolone – 5 mg per day.

Rheumatoid administered intramuscularly 1.3 ml of a daily basis for 7-14 days, then two times a week. The course of treatment is 16 weeks. Intranasal  is prescribed primarily as a maintenance therapy and prevention of relapse 1-2 ml nasal drops in each nostril for 5-10 days, then 2 times a week.

Application after cytostatic therapy to reduce myelotoxic actions of cytostatic therapy  administered intramuscularly daily for 5-7 days -2 to 1 ml. The introduction of the drug is started 24 – 48 hours prior to the first course of cytostatic chemotherapy (1st and 2nd administration). Third introduction produce 12 hours before the start of chemotherapy. Depending on the duration of the chemotherapy drug continues to be administered daily for 1-2 ml of 1 time per day. The main performance indicator – the number of white blood cells and granulocytes for 3 days before the start of the next course of cytotoxic therapy. The drug can also be administered intranasally 1-2 ml nasal drops in each nostril, or fractional 0.5 ml in each nostril 2-3 times a day, starting 24-48 hours prior to the first course of chemotherapy.  Menis indicated for use prior to chemotherapy courses having a duration not longer than 2 weeks and breaks at least 2 weeks. During long-term, continuous dosing cytostatics its use is impractical. In recurrent course of primary and secondary autoimmune cytopeniasclomid for men is recommended as the first 2 courses of injection, and then at the positive effect of a transition to the course application of the drug intranasally in a few months to stabilize the process. When little effect on the first courses of the drug is recommended to increase the daily dose 2-3 times and reduce the break between courses to 7 days. After reaching effect it is necessary to carry out supporting exchange treatment, during which the dose of the drug can be reduced, and a break between courses to increase. In severe recurrent course thymodepressin ® is administered in combination with a cytotoxic immunosuppressive agents, the dose of which is reduced by 2 times, and when the effect of cytotoxic immunosuppressive canceled . dosage in pediatric practice: Children from 2 to 12 years thymodepressin ® administered intramuscularly at 0.5 -1 ml solution for intramuscular or intranasal 0.5-1 ml nasal drops into each nasal passage 1 time per day for 7-10 days, then break for 2 days and, if necessary, the repetition rate. Possibly carrying 1 to 5 courses. Children older than 12 years thymodepressin ® administered intramuscularly, 1-2 ml solution for injection or intranasally 1-2 ml nasal drops into each nasal passage 1 time per day for 7-10 days, then break for 2 days, then 1-2 course in 7-10 days.

 

Side effect :
After the second treatment  possible transient reduction in the number of white blood cells while preserving peripheral blood leukocyte.

Overdose :
Cases of overdose when using the drug are unknown.

Interaction with other drugs :
not recommended given simultaneously with drugs that provide immunostimulatory effects.
When combined with cytostatics ® does not reduce their anti-tumor effect.

Special instructions :
Application clomid for men® , as well as other immunosuppressive agents, predisposes to exacerbate latent bacterial, fungal, parasitic and viral infections. At the first clinical signs of infection, you must assign the appropriate pathogenetic therapy. If you notice an unexpected effect of the drug should consult a doctor.

Product form : solution for intramuscular administration of 1 mg / ml. 1 ml in neutral glass ampoules. 5 vials in blisters  film. One or two blisters with instruction on the use of a knife and lancet ampoule or ampoule is placed in a pile of cardboard. When packing ampoules with a ring or point of fracture knives ampoule or ampoule scarifiers do not invest. Nasal drops 0.1% In 5 mL vials of neutral glass. The vials are sealed with rubber stoppers and aluminum caps run in. 1 bottle complete with cork or cap-pipette dropper and instruction for use is placed in a pile of cardboard boxed.

 

clomid side effects

For parenteral administration, the systemic circulation misses about 90% of the drug when administered intranasally bioavailability also is not less than 90%. The maximum concentration clomid side effects in the systemic circulation is achieved in 5 minutes after its parenteral administration. Absorption: When applying intranasal absorption occurs with the nasal mucous membranes. For parenteral administration the absorption of the drug occurs at the site of injection.

Metabolism: Preparation of 70% is metabolized in the liver. The distribution: maximum concentration in organs and tissues is achieved within 15 minutes after administration. In bone marrow and liver greater than that in the blood of 9.5 and 3.45 times respectively. The plasma concentration above 1.5 times, that is, the drug accumulates predominantly in the plasma, not the elements of blood. Derivation: For parenteral and intranasal administration excretion comes with urine (55- 59%) and the feces (13 – 19%). The half-life is about 14 hours. The drug clomid side effects is completely eliminated within 24 hours and does not accumulate in the body.

Indications for use : clomid side effects is used in adults and children 2 years of age, is used both in monotherapy and in treatment and prevention of recurrence of a variety of autoimmune diseases:

  • Chronic recurrent dermatoses: (psoriasis, pemphigus, atopic dermatitis, eczema, symptomatic treatment of T-cell lymphoma of the skin);
  • Autoimmune connective tissue disease: (rheumatoid arthritis and other autoimmune connective tissue diseases rheumatoid secondary lymph background syndrome and other tumors.) autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, di- and trehrostkovye cytopenias, including – for secondary background lymphocytic lymphoma and chronic lymphocytic leukemia. The treatment regimen is adjusted individually. :
  • in cytostatic chemotherapy and radiation therapy for the protection and preservation of stem cells and accelerate the exit from granulocytopenia;
  • for the prevention of graft rejection in transplantation of organs and tissues;
  • bone marrow transplant to prevent graft rejection.Contraindications : Contraindications to the use of the drug is pregnancy, lactation, uncontrolled hypertension, infectious and viral diseases in the acute phase, the drug idiosyncrasy.

    Dosage and administration : Chronic recurrent dermatoses Psoriasis clomid side effectsis administered intramuscularly, 1-2 ml of the solution on a daily basis for 7-10 days, then 2 days break and re-7-10-day administration cycle. Depending on the clinical situation can be carried out from 3 to 5 cycles. Repeated cycles can be carried out up to 5 times. Intranasal administered primarily as maintenance therapy and prevention of relapse, as well as in the treatment of children. The drug is administered by nasal drops 2.1 ml into each nostril for 10-14 days. In patients clomiphene citrate bodybuilding with generalized erythroderma psoriasis administered intramuscularly in 2 ml daily for 14 days followed by 14 days intranasally with simultaneous addition of glucocorticoid hormones in medium doses (40-60 mg of prednisolone).

  • Atopic dermatitis is administered intramuscularly, 1-2 ml of the solution on a daily basis for 7-14 days, the treatment may be extended after a 2-day break. Duration of the course and the number of defined clinical and morphological features of the disease. Intranasal drug prescribed mainly as a maintenance therapy and prevention of relapse or treatment of children.Children appoint 1-2 ml nasal drops in each nostril for 7 days followed by 2 days rest and repeated 7-day course. Eczema clomid side effects is administered intramuscularly, 1-2 ml of solution every day for 10 days, then 2- 5 days – a break, and again repeat the 10-day administration cycle. Intranasal drug prescribed mainly as a maintenance therapy and prevention of relapse or treatment of children. Children appoint 1-2 ml nasal drops in each nostril for 10 days, followed by 2-5 days rest and repeated 10-day course. T-cell lymphoma of the skin of the drug in this disease is administered intramuscularly to 2 ml daily three 7- day course with 5 -. day intervals against the backdrop of moderate doses of corticosteroids (30-40 mg of prednisolone) pemphigus drug is used in a variety of species in the complex treatment of pemphigus with corticosteroids.