chlomid

The main pathway – oxidation and chlomid conjugation. The volume of distribution – about 450 ml / kg. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half-life – 20 -50 minutes. The total plasma clearance – 10-15 ml / min.

Indications

Diabetic and alcoholic polyneuropathy.

Contraindications

Hypersensitivity to thioctic acid or other ingredients.

Pregnancy, lactation (not enough experience with the drug).

Clinical data on the use of the drug chlomid  in children and adolescents lacking in this regard to children and adolescents should not be prescribed the drug.

 

Dosing and Administration

The drug is used intravenously. The recommended dose for severe polyneuropathy is 1 vial (600 mg) 1 times a day for 2-4 weeks.

Subsequently, the patient is transferred to the treatment with Thioctacid ® BV is 600 mg (1 tablet) per day.

Intravenous administration of the drug should be carried out slowly (not faster than 2 ml / min).

Intravenous administration is also possible by using undiluted solution injection syringe and pump reliability. In this case, the time of administration should be not less than 12 minutes.

Because of the sensitivity to the light chlomid of the active substance, ampoules must be removed from the carton immediately prior to use.

Recommendations for infusion

The infusion solution should be protected from light (eg by wrapping the container with aluminum foil).

Solution for intravenous administration, protected from light, fit for 6 hours.

Allergic reactions:

Rarely – skin rash, hives, itching, eczema, redness of the skin, systemic allergic reactions up to anaphylactic shock.

From the nervous system and sensory organs: very rare – convulsions, diplopia.

From the blood and circulatory system:

Very rarely – purpura, petechiae and bleeding tendency (due to platelet function disorders), thrombocytopathy, thrombophlebitis.

General nature:

Often – by rapid intravenous injection can be observed an increase in intracranial pressure and difficulty breathing, which chlomid independently tested.

Nechasto- impaired sense of taste (metallic taste).

Rarely allergic reactions may occur at the site of infusion.

Rarely – nausea and vomiting.

Very rare – due to improved glucose utilization may decrease the level of glucose in the blood and appear symptoms of hypoglycemia (confusion, sweating, headache, visual disturbances).

 

 

Overdose

Cases of drug overdose thioctic acid in the form of a solution is not observed for intravenous administration.

If peredozirovki- symptomatic treatment, if necessary – anticonvulsant therapy, measures to support the functions of vital organs.

 

Interaction with other drugs

When concomitant administration of thioctic acid and cisplatin marked decrease in the efficiency of cisplatin. With simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs their action can be amplified, so we recommend regular monitoring of blood glucose levels, especially at the beginning of therapy thioctic acid. In some cases the permissible reduction in the dose of hypoglycemic drugs to prevent the development of symptoms of hypoglycemia.

Ethanol and its metabolites weaken the effect of thioctic acid.

 

special instructions

Thioctic acid infusion solution is incompatible with dextrose, Ringer’s solution, and solutions of reacting with disulfide  with ethanol. Alcohol consumption is a risk factor for the development of polyneuropathy and may decrease the effectiveness of the drug , so patients should abstain from alcohol during treatment as a drug, and in the periods outside of treatment.

diabetic polyneuropathy Treatment should be carried out against the background of maintaining optimal blood glucose levels.

 

release Form

A solution for intravenous administration of 25 mg / ml.

In 24 ml of solution in a dark glass vial, hydrolytic type 1 Directly on the vial marked to show the place chlomid of application of force for opening the ampoule: two rings of red and white point.

5 vials in a plastic tray white, 1 pallet together with instructions for use in a cardboard box.