clomiphene citrate for men

Endogenous antioxidant (binds free radicals) in the body is produced in the oxidative decarboxylation of alpha-ketoksilot. As coenzyme mitochondrial multienzyme complexes involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Thereby reducing blood glucose and increased glycogen concentration in the liver, as well as overcome the insulin resistance. By the nature of the biochemical action similar to B vitamins involved in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, improves liver function. It has hepatoprotective, hypolipidemic, cholesterol-lowering, the hypoglycemic effect. Improves trophic neurons. Using the meglumine salt of thioctic clomiphene citrate for men acid in solution for intravenous administration (having a neutral reaction) reduces the severity of side reactions.

Pharmacokinetics

When ingestion rapidly and completely absorbed from the gastrointestinal tract (reception with food reduces the absorption). maximum concentration time – 40-60 minutes. Bioavailability – 30%.

It has the effect of “first pass” through the liver. The formation of metabolites occurs as a result of oxidation of the side chain and conjugation.

The volume of distribution – about 450 ml / kg. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half – 20-50 minutes. The total plasma clearance – 10-15 ml / min.

When administered intravenously, the time to reach maximum concentration – 10-11 minutes, the maximum concentration – 25-38 mg / ml. The area under the curve of concentration – time – about 5 ug h / mL.

Indications for use

  • Diabetic polyneuropathy.
  • alcoholic polyneuropathyContraindications

    Hypersensitivity to the drug.

    Pregnancy during breastfeeding.

    Children’s age clomiphene citrate for men (efficacy and safety have not been established).

    Dosing and Administration

    Inside designate 600 mg 1 time per day. The tablets are not liquid, squeezed small amounts of liquid.

    The drug is also administered intravenously at a dose of 600 mg per day (1 ampoule concentrate for solution for infusion of 30 mg / ml or 1 bottle for infusion solution 12 mg / ml). At the beginning of the course the drug is administered intravenously for 2-4 weeks. Then the ingestion of the drug can be continued at a dose of 300-600 mg per day. The drug should be administered slowly, there is a maximum of 50 mg thioctic acid for 1 minute (which is equivalent to 1.7 ml concentrate for solution for infusion of 30 mg / ml).

    Regulation of a solution
    Content 1 ampoule (content equivalent to 600 mg of thioctic acid) is mixed with 50-250 ml of 0.9% sodium chloride and administered as an infusion over 20-30 minutes. Infusion produced from the flasks are placed in the enclosed lightproof suspension housings made of black polyethylene. When applying the solution for infusion in vials infusion  produced directly from these vials are placed in the enclosed lightproof suspension housings made of black polyethylene. Side effect

    When ingestion possible indigestion, including nausea, vomiting,

    Following intravenous administration rarely possible convulsions; diplopia; petechial hemorrhages in the mucous membranes, skin; thrombocytopenia purpura (purpura), thrombophlebitis; the rapid introduction may increase intracranial pressure (the emergence of a feeling of heaviness in the head); difficulty breathing. These side effects are alone.

    Allergic reactions: urticaria, systemic allergic reactions (up to the development of anaphylactic shock). Perhaps the development of hypoglycemia (due to improved glucose uptake).

    Overdose

    Symptoms include nausea, vomiting, clomiphene citrate for men headache. Treatment is symptomatic. Net.Vzaimodeystvie specific antidote with other drugs In vitro thioctic acid reacts with the metal ion complexes (e.g., cisplatin), and therefore while applying Tiogamma O (solution for infusion) may reduce the effect of cisplatin. Since sugar molecules thioctic acid forms poorly soluble complex compounds. Consequently, thioctic acid infusion solution is incompatible with dextrose, Ringer’s solution and solutions which can be reacted with compounds of SH-groups or having disulfide links. In an application Tiogamma O enhances the action of insulin and oral hypoglycemic agents. Alcohol (ethanol) reduces the therapeutic activity of thioctic acid.

    special instructions

    Patients taking t , should refrain from the use of alkogolya.U patients with diabetes requires constant monitoring of blood glucose levels, especially in the early stages of therapy. In some cases it is necessary to reduce the dose of insulin or oral hypoglycemic drug, in order to avoid hypoglycemia.

    Product form
    Film-coated tablets, 600 mg. 10 tablets in blister packs. At 3, 6, or blisters with instruction on use is placed in a cardboard box.
    The concentrate for solution for infusion 30 mg / ml in dark glass vials of 20 ml. At 5, 10, or 20 vials with hanging light protective sheath made of black polyethylene, and instructions for use are placed in a cardboard box.
    The solution for infusion 12 mg / ml in dark glass bottles of 50 ml; 1 or 10 vials with outboard clomiphene citrate for men on the number of bottles made from polyethylene black and instructions for use are placed in a cardboard box.

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