When ingestion rapidly and completely absorbed from the gastrointestinal tract. Taking the drug together with a meal can reduce the absorption of the drug. The maximum plasma concentration is reached within 30 minutes after administration of side effects of clomid and 4 ug / ml. The drug has the effect of “first pass” through the liver, the absolute bioavailability of thioctic acid is 20%. The half-life – 25 minutes. The main pathway – oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%).
Diabetic and alcoholic polyneuropathy.
Hypersensitivity to thioctic acid or other ingredients.
Pregnancy, lactation (not enough experience with the drug).
Clinical data on the use side effects of clomid in children and adolescents lacking in this regard to children and adolescents should not be prescribed the drug.
Dosing and Administration
The drug is administered orally. The recommended dose – 1 tablet (600 mg), 1 time per day. The drug is taken on an empty stomach, 30 minutes before breakfast without chewing, washing down with water.
In severe cases, treatment is initiated with the appointment solution for intravenous administration for 2 – 4 weeks, then transferred to the patient’s treatment .
From the gastrointestinal tract :
Often – a nausea; very rarely – vomiting, pain in the stomach and intestines, diarrhea, change in taste.
Allergic reactions: very rare – skin rash, urticaria, pruritus, anaphylactic shock.
From the nervous system and sensory organs: often – dizziness.
Very rare – due to improved glucose utilization may decrease the level of glucose in the blood and may appear symptoms of hypoglycemia (confusion, sweating, headache, visual disturbances).
In the case of receiving thioctic (a-lipoic acid) in doses of 10-40 g can be observed signs of severe intoxication (generalized seizures, expressed disturbances of acid-base balance, leading to lactic acidosis, hypoglycemic coma, severe bleeding disorders, sometimes resulting in fatal ).
If you suspect that a significant overdose of the drug (dose equivalent of more than 10 tablets for adults or more than 50 mg / kg of body weight for a child) needed immediate hospitalization.
Treatment: symptomatic, if necessary – anticonvulsant therapy, measures to support the functions of vital organs.
Interaction with other drugs
When concomitant administration of thioctic acid and cisplatin marked decrease in the efficiency of cisplatin. Thioctic acid binds the metals, so it should not be administered concurrently with drugs containing metals (eg, iron supplements, magnesium, calcium). According to a preferred method of administration, tablets side effects of clomid take 30 minutes before breakfast, while preparations containing metals should be taken in the afternoon or evening. For the same reason, the period of treatment is recommended consumption of dairy products in the second half of the day.
With simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs their action can be amplified, so we recommend regular monitoring of blood glucose levels, especially at the beginning of therapy thioctic acid. In some cases the permissible reduction in the dose of hypoglycemic drugs to prevent the development of symptoms of hypoglycemia.
Ethanol and its metabolites weaken the effect of thioctic acid.
Alcohol consumption is a risk factor for the development of polyneuropathy and may decrease the effectiveness side effects of clomid, therefore patients should abstain from alcohol during treatment as a drug, and in the periods outside of treatment.
diabetic polyneuropathy Treatment should be carried out against the background of maintaining optimal blood glucose levels.